学术报告
报告题目:Antiviral RNAi in plants and mammals
报告地点:昆明市北京路2238号云南省农业科学院行政楼2楼1会议室
报告时间:2018年7月4日星期三上午 9:30
报告人:Dr. Shouwei Ding
Professor of Molecular
Virology and Immunology,University of California, Riverside
Fellow of American Association for the Advancement of Science, Fellow of American Academy of Microbiology
邀请人:张仲凯研究员,云岭学者云南省农业科学院生物技术与种质资源研究所
丁守伟博士,美国加州大学河滨分校终身教授,美国科学促进会会士,国际著名植物病理学家、分子病毒学家,主要从事宿主RNA干扰(RNAi)抗病毒机制和病毒的反防御机制研究。在Science、Nature、Cell等顶尖科学杂志发表多篇重要影响力科研论文。
Key
publications:
2017.Lipid
flippases promote antiviral silencing and the biogenesis of viral and host
siRNAs in Arabidopsis. ProcNatlAcadSci USA.114:1377-1382.
2017.Viral effector protein manipulates host hormone signaling to attract insect vectors. Cell Res27(3):402-415
2016. Induction
and suppression of antiviral RNA interference by influenza A virus in mammalian
cells. Nature Microbiol2:16250.
2014.Virus
infection triggers widespread silencing of host genes by a distinct class of
endogenous siRNAs in Arabidopsis.ProcNatlAcadSciUSA111(40):14613-8
2013. RNA interference functions as an antiviral immunity mechanism in mammals. Science 342:231-234.
2012. Homology-independent
discovery of replicating pathogenic circular RNAs by deep sequencing and a new
computational algorithm. ProcNatlAcadSci
USA 109:3938-3943.
2011. The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative Argonautes in Arabidopsis thaliana. Plant Cell 23:1625-38.
2010.RNAi-mediated
viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana. ProcNatlAcadSci USA.107,484-489.
2010. Virus
discovery by deep sequencing and assembly of virus-derived small silencing
RNAs.ProcNatlAcadSci USA.107,1606-1611.
2010.RNA-based
viral immunity. Nature Rev Immunol10:632-44.
2009.An RIG-I-like
RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditiselegans. PLoS Pathogens5(2): e1000286
2008. Mechanism of
induction and suppression of antiviral immunity directed by virus-derived small
RNAs in Drosophila. C ell Host & Microbe4:387-397.
2007.Antiviral immunity directed by small RNAs. Cell 130:413-426.
2006.RNA
interference directs innate immunity against viruses in adult Drosophila. Science 312:452-454.
2005.Animal virus
replication and RNAi-mediated antiviralin Caenorhabditiselegans. Nature 436:1040-1043.
2004. Three
distinct suppressors of RNA silencing encoded by a 20-kb viral RNA genome. ProcNatlAcadSci USA101:15742-15747.
2004.Interferon
antagonist proteins of influenza and vaccinia viruses are suppressors of RNA
silencing.ProcNatlAcadSci USA101:1350-1355.
2002. Induction and suppression of RNA silencing by an animal virus. Science 296,1319-1321
欢迎广大科研人员和研究生光临!